Jean-Philippe KRIEGER
MSc Nutrition Physiology
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My research
- How does the human body harvest energy from food?A question more difficult to answer than we thought it was!
This simple question was my leitmotif since I graduated and it took me from sports nutrition to gut microflora.
I started as a sports nutrition consultant for an international sports company, with a special focus on exogenous carbohydrate oxidation.
Today, I am amazed by the emerging field of gut microbiota, which has recently been shown to modulate our energy harvest from food and to play a role in metabolic disorders or immunity.
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My past research
- From genetics to environmental microbiology, I've had the chance to acquire a broad skill set in some of the foremost labs in their respective fields.Quantitative genetics, molecular biology
- The lab : it aims at understanding the genetic basis of adaptation and response to abiotic stress in Arabidopsis thaliana. Natural variation is used as a source of
biodiversity to find new genes and new alleles controlling shoot and
root growth under abiotic stresses.
- My work : revealing molecular basis of a particular root phenotype under drought stress using QTL mapping and positional cloning approach.
Proteomics, gene silencing- The lab : the main area of research in this lab is aimed at understanding the molecular mechanisms underlying the overexpression of a pivotal Alzheimer’s disease (AD)-related protein, BACE1. Dr Holsinger’s team have recently achieved great success in downregulating the BACE1 gene using RNAi and are currently pursuing a clinical application of this target.
My work : RNA design and gene silencing using shRNAs to dowregulate BACE1 expression in cultured cells.
Systems biology, marine microbial ecology- The lab : it aims to better understand 1) how environmental forcing such as UV radiation or contaminants impact microorganisms and 2) how microorganisms through their specific functions affect the marine biogeochemical cycles of the major elements C, N and P, and the trace metal Fe.
- My work : genetic engineering of a microbial biosensor able to detect and respond to low concentrations of hydrocarbons in sea water.
- The lab : it aims at understanding the genetic basis of adaptation and response to abiotic stress in Arabidopsis thaliana. Natural variation is used as a source of
biodiversity to find new genes and new alleles controlling shoot and
root growth under abiotic stresses.
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Info
- Ph.D student at ETH Zürich, Nutrition physiology / Control of energy intakeResearch | Zürich Area, Switzerland, CHSummaryAs a Life sciences engineer, my educational background was particularly research-oriented, dealing especially with human health. Finally focusing on human nutrition, I was able to get scientific and technical skills in this field. I also had the opportunity to get professionally involved in the world of sport, which I particularly appreciated as a person. Today, I lead research projects in the field of sports nutrition.
Above all, I am particularly interested in the way the human body harvests energy from food. Consequently, I took the decision to start a Ph.D at ETH Zürich in nutrition physiology (physiological control of food and energy intake).Specialties: Sports nutrition : - Clinical studies preparation and follow-up - Computer simulation - Literature review - Nutrition products formulation Control of food and energy intake : - feeding-regulatory hormones (leptin, GLP-1, PYY, ...) - central and peripheric mechanisms Fundamental research tools : - "omics" - gene silencing - rats and mice surgeryExperience- May 2012 - PresentPh.D student / ETH, Swiss Federal Institute of Technology, ZurichControl of food and energy intake
- Oct 2010 - Apr 2012Research engineer, Sports Nutrition / Oxylane ResearchInitiation, realization and follow-up of sports nutrition research studies
- Mar 2010 - Sept 2010Product engineer - Sports nutrition (Intern) / Aptonia (nutrition et soins du sportif, Decathlon)Formulation of a whole range of isotonic sport drinks
- Sept 2009 - Mar 2010End-of-study project / ANSESExposure of the French population to food additives of natural origin : assessment and prospects
- Mar 2009 - Aug 2009Intern / CNRSBiodetection of oil pollution in marine waters using a genetic-engineered bacteria
- Sept 2008 - Mar 2009Intern / Brain and Mind Research Instituteβ‐secretase regulations in Alzheimer’s disease
- Jul 2007 - Aug 2007Intern / INRAArabidopsis thaliana genetic variability and stress tolerance
Education-
2006 - 2010AgroParisTech - Institut des sciences et industries du vivant et de l'environnementEngineer (M2) in Nutrition and Health
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2008 - 2008Technische Universität München
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